Journal of Clinical and Experimental Ophthalmology
Open Access

Abstract

To Study the Effect of Oral Vitamin D Supplementation in Dry Eye Patients in a Tertiary Eye Care Center

Anurag Kumar Kashyap, Diksha Sareen, Deepak Mishra, Archana Yadav*, OPS Maurya, SK Singh

Purpose: To establish possible association between serum vitamin D deficiency and dry eye disease and determine beneficiary effect of vitamin D supplementation in dry eye patients.

Materials and methods: A randomized controlled clinical study was conducted in a hospital-based tertiary eye care center including 497 outpatients between age group 18-58 years. Patients were screened randomly for dry eye. Tear film Break-Up Time (TBUT), Schirmer’s test and Ocular Surface Disease Index (OSDI) were used to diagnose dry eye.

Results: Forty patients were diagnosed with dry eye. After vitamin D supplementation in dry eye patients, TBUT and schirmer’s score was found to be significantly higher at 2 weeks (p<0.001) and at 6 weeks of treatment (p<0.001). Also, OSDI score was significantly lowered at 6 weeks of treatment (p<0.001).

Conclusion: Supplementation of oral vitamin D improved tear secretion and reduced tear instability as indicated by development of Schirmer's score and tear breakup time. Also, higher OSDI scores and lower TBUT value and schirmer’s scores in vitamin D deficient patients indicates positive correlation between serum vitamin D level and dry eye disease.

Published Date: 2025-04-11; Received Date: 2023-09-07