Journal of Probiotics & Health
Open Access

Abstract

The Effect of Bacillus subtilis DE111 on the Daily Bowel Movement Profile for People with Occasional Gastrointestinal Irregularity

Ana Maria Cuentas, John Deaton, Sonaina Khan, John Davidson and Courtney Ardita

Objective: Bacillus subtilis probiotics have been shown to influence several aspects of the human gut including motility, epithelial strength, inflammation, etc. that may change bowel movement frequency and/or type. To explore the efficacy of Bacillus subtilis (B. subtilis) DE111 in this regard, 50 people were evaluated by their stool profile, food diary and questionnaire while taking a probiotic or placebo daily over the course of 105-days.
Method: The stools were scored based on the Bristol Stool Chart index and safety was assessed using blood markers during the 0, 45 and 105 days.
Results: Statistically significant results showed those in the DE111 group moved to a healthier bowel index while those in the Placebo group stayed the same.
Conclusion: The study provided evidence that DE111 may improve occasional constipation and/or diarrhea in healthy individuals.