Despite the dramatic development of enantioselective synthesis and chromatographic separation methods, optical resolution still remains the cheapest and operationally simplest method for producing pure enantiomers on a larger scale. The preparation of pure enantiomers due resolution is based on the formation of homo- and heterochiral supramolecular associations in the solutions of mixtures of chiral compounds. According to their selfdisproportionation (SDE)  these are distributed between phases. In this paper some methods are described, which were developed by our research group for the separation of enantiomeric and diastereomeric mixtures. The examples are mainly based on the long experience of our research group in the resolution of industrially important molecules. A presumable mechanism is also presented, which assume that the distribution follows the equilibrium of homo- and heterochiral double helical structures formed due the interactions.
Published Date: 2019-08-26; Received Date: 2019-08-08