Angiology: Open Access
Open Access

Abstract

Relationship between Preoperative Urinary Microalbumin to Creatinine Ratio Level and Contrast-induced Nephropathy after Elective Coronary Angiography/Percutaneous Coronary Intervention

Changle Ma, Chengchun Tang, Yuhan Qin, Gaoliang Yan and Genshan Ma

Objective: To investigate the predictive value of preoperative urinary microalbumin to creatinine ratio (UACR) level for early diagnosis of contrast-induced nephropathy (CIN).

Methods: A total of 180 patients scheduled to undergo elective coronary angiography (CAG)/percutaneous coronary intervention (PCI) in our department from November 2016 to September 2017 were selected into this prospective study. Patients were allocated to high UACR group (UACR ≥ 30, n=35) and control group (UACR<30, n=145) according to the UACR level. The patients were also divided into CIN group (n=32) and no CIN group (n=148). Multivariable logistic regression model was used to investigate the risk factors of CIN. This trial was registered on the Chinese Clinical Trial Registry on 23 May 2017 (Registration No. ChiCTR-OOC-17011467).

Results: 32 patients developed CIN (17.78%). The incidence of CIN was significantly higher in high UACR group than in the control group (P0.001). The ratio of high UACR in CIN group was significantly higher than no CIN group (P0.001). Multivariable logistic regression analysis indicated that preoperative UACR level (P0.001, 95%CI: 3.81929.223, OR: 10.564) was an independent risk factor of CIN.

Conclusion: Preoperative UACR level appears to be an independent predictive factor for early diagnosis of CIN.