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Pediatrics & Therapeutics

Pediatrics & Therapeutics
Open Access

ISSN: 2161-0665

+44 1478 350008

Abstract

Acute Demyelinating Encephalomyelitis (ADEM): Clinical Characteristics and Outcome

Ahmed Farag Elhassanien, Hesham Abdel-Aziz Alghiaty and Mohamed Zakaeria

Background: ADEM, although relatively uncommon, is probably under-recognized.
Objectives: To spotlight on the clinical profile and therapeutic outcome of children with ADEM.
Methods: This is a prospective study of patients with ADEM who were admitted to the Pediatric Departments in Aladan and Alfarawanya Hospitals in Kuwait, from January 2009 to January 2011. Clinical, microbiological, radiological and therapeutic data were analyzed.
Results: Of 48 patients presented with acute neurological symptoms and signs, 21 patients fulfilled criteria for ADEM. 80.95% of cases were presenting in winter and spring, 57% of patients had a history of upper respiratory tract illness. The commonest presentations were motor deficits, convulsions followed by altered conscious. CSF virology studies showed Herpes Simplex Virus (HSV) and Epstein-Barr virus (EBV) in 3 patients whereas nasal and nasopharyngeal swab showed evidence of influenza H1N1 virus in 1 patient. Brain MRI was performed in all patients and revealed multiple hyperintense supratentorial brain lesions on T2/FLAIR images. 85.7% of patients had cortical and/or subcortical white matter lesions which were bilateral and asymmetric in location and size. Most of the patients were treated with steroids alone, 3 patients received high-dose intravenous methylprednisolone and 6 patients received both steroids and intravenous immunoglobulin.

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