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Vitamin D and congenital ichthyosis: a case series in India | 10636
Journal of Clinical & Experimental Dermatology Research

Journal of Clinical & Experimental Dermatology Research
Open Access

ISSN: 2155-9554

+44 1478 350008

Vitamin D and congenital ichthyosis: a case series in India


12th Global Dermatologists Congress

August 31-September 01, 2017 London, UK

Priyanka Hemrajani

Kempegowda Institute of Medical Sciences, India

Posters & Accepted Abstracts: J Clin Exp Dermatol Res

Abstract :

Introduction: Ichthyosis, a genetic disorder of keratinization, is characterized by excessive scaling associated with epidermal hyper proliferation and/or cellular retention. Normally, thickness of the outer epidermis is 25 �?¼m and that of a patient of Ichthyosis is 10 folds greater. This impairs photo activation of 7-dehydrocholesterol and causes systemic vitamin D deficiency. Materials & Method: This was a prospective observational study performed at Kempegowda Institute of Medical Sciences, Bengaluru, India. Patientâ�?�?s clinical characteristics were recorded. Serum concentration of 25-hydroxyvitamin D was determined along with serum calcium, phosphorus and parathyroid hormone. X-rays of the bilateral wrists and knee joints in antero-posterior and lateral views were done. Case series of 12 patients with vitamin D deficiency was correlated with calcium, phosphorus, parathyroid hormone levels and radiological findings. Results: Out of 12 patients of congenital ichthyosis, six were males and six females. Out of these 12, only two had vitamin D sufficiency. For 10 patients with vitamin D below the optimal level (<30 ng/ml), following are the tested vitamin D levels: Vitamin D >20 ng/ml but <30 ng/ml â�?�? two patients; vitamin D >10 ng/ml but <20 ng/ml- two patients; vitamin D <10 ng/ml â�?�? six patients. Serum calcium and phosphorus were normal for all patients; two patients had hyperparathyroidism; radiologically, two patients had genu valgum and one patient had rickets. Conclusion: Vitamin D plays a vital role in patients of congenital ichthyosis and it should be tested for every patient of congenital ichthyosis as it would help in better prognosis and management of the patients.

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