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Virological success in early treated HIV-infected infants: evalua | 6719
Journal of Antivirals & Antiretrovirals

Journal of Antivirals & Antiretrovirals
Open Access

ISSN: 1948-5964

+44 1300 500008

Virological success in early treated HIV-infected infants: evaluation after 2 years of cART in the PEDIACAM study, Cameroon


2nd International Conference on Retroviruses and Novel Drugs

June 30-July 01, 2016 Cape Town, South Africa

Ateba Ndongo Francis

Centre M�?¨re et Enfant de la Fondation Chantal Biya Yaound�?©, Cameron and Universit�?© Paris-Sud, Le Kremlin-Bic�?ªtre, France.

Posters & Accepted Abstracts: J Antivir Antiretrovir

Abstract :

To our knowledge there are few data concerning the effect of socio-economic and familial environment on virological outcomes of cART in HIV-infected infants. In this study, we evaluated the probability of and identified factors associated with a first confirmed virological success (CVS) in HIV-infected infants within the first two years after cART start. We included 190 infants who started cART no later than age 12 months. The main outcome variable was time from cART initiation to a first confirmed virological success (CVS), defined as having plasma HIV RNA levels of <1000 copies/mL in two successive visits (3 months) on three successive visits (6 months). Time-to-event analysis was the primary method of analysis. Cumulative incidence of the outcome was calculated. Univariate and multivariable competing-risks regressions were fitted to assess association between the outcome and the exposure variables in the presence of competing death. In our study, cumulative incidence of CVS was 38.4% (73/190), almost all of these successes occurring before one year of cART (36.8%). Virological response was better in infants recruited in the Yaound�?© sites (CHE and CME) than in the Douala site (HLD) (p=0.034). The likelihood of achieving a first CVS was unrelated to clinical, immunological, virological and other baseline socio-demographic characteristics of the infants (p�?�?0.05). Socio-demographic characteristics are not a barrier to virological success in HIVinfected infants started on combined antiretroviral therapy in a low-resource setting with free of charge care system. Further studies are needed to understand the effect of healthcare provision system of health facilities on virological success in HIVinfected infants started on cART.

Biography :

Email: atebfranc@gmail.com

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