Journal of Antivirals & Antiretrovirals
Open Access
ISSN: 1948-5964
ISSN: 1948-5964
Yanwei Zhong, Shishu Zhu, Hongfei Zhang, Dongping Xu, Yi Dong, Dawei Chen, Yu Gan, Fuchuan Wang, Dongqing Zhou and Yan Wang
Scientific Tracks Abstracts: JAA
Background: Th e association of hepatitis B virus(HBV) genotypes/subgenotypes with clinical characteristics is increasingly recognized. However, the virologic and clinical features of HBV genotypes/subgenotypes in pediatric patients remain largely unknown. Purpose: To analyze the relationship among the genotypes/subgenotypes and NA resistance as well as the disease progression in pediatric patients with CHB. Methods: Four hundred and eighty-seven pediatric patients with CHB were investigated, including 217 nucleos(t)ide analog-experienced patients. HBV genotypes/subgenotypes and reverse transcriptase (RT) mutations were determined by direct sequencing. Th e stage of fi brosis and degree of infl ammatory activity were evaluated by the Metavir score system. Results: Among 487 enrolled pediatric patients, HBV genotype C2 and B2 were the most two prevalent(73.7% and 21.1%). Th e subgenotype distribution were as follows: 1(0.2%) for B1, 103 ( 21.1%) for B2, 1 ( 0.2 %) for B3, 3(0.6%) for B4, 7 (1.4%)for C1, 359 ( 73.7%) for C2, 5 ( 1.0 %) for C3, 2 ( 0.4%) for C4, and 6( 1.2 %) for D, No other genotypes (A, E, F, G, or H) were detected in enrolled samples of this study. Comparing with HBV/B2 infected patients, no signifi cant diff erence was observed in the incidence rate and mutant patterns of lamivudine- or adefovirresistant mutations in HBV/C2 infected patients (P > 0.05). Importantly, we found that hepatic infl ammation degree, fi brosis stage and ALT level were signifi cantly higher in HBV/C2-infected HBeAg positive patients than did HBV/B2-infected ones. Conclusion: Th e pediatric patients with HBV/C2 infection were more susceptible to develop severe liver pathogenesis.