Journal of Antivirals & Antiretrovirals
Open Access

Tuberculosis (TB) drug resistance is a global treat now a days

2^nd International Conference on Retroviruses and Novel Drugs

June 30-July 01, 2016 Cape Town, South Africa

Girma Misgana

Adama Hospital Medical College, Ethiopia

Posters & Accepted Abstracts: J Antivir Antiretrovir

Abstract :

Background: Tuberculosis (TB) drug resistance is a Global treat now a days. The impact of Multi drug resistant tuberculosis (MDR-TB) is dangerous especially in resource limited countries like Ethiopia because of its financial and skilled human power required for diagnosis and management Objective: The study aim was to determine risk factors for tuberculosis (TB) caused by multi drug resistant Mycobacterium tuberculosis (MDR-TB) in Oromia region, Ethiopia. Methods: In a 6 months case control study in 2013-14, sputum samples and standardized questionnaire data (demographics, treatment, TB contact history, underlying disease, history of imprisonment) were collected from suspected MDR-TB cases>18 years of age. Sputum was processed locally in the Oromia public health laboratory using standard techniques. Data from MDRTB cases and TB positive controls were compared using logistic regression analysis. For each factors, their association with outcomes variable was estimated by calculating the odd ratio (OR) together with 95% confidence intervals (95% CI). Results: Of 439 suspected MDR-TB cases, 265 had confirmed Mycobacterium tuberculosis infection, of whom 33% (88) had laboratory, confirmed MDR-TB. Over two thirds (65%) were between18 to 39 years of age. On multivariable analysis occupation (farming), known TB contact history, alcohol use, HIV infection, previous known TB history and previous TB treatment outcome were predictors of MDR-TB. Conclusion: The rate of MDR- TB was high among suspected cases in the Oromia region of Ethiopia. Local MDR-TB detection capacity and local epidemiology studies are key for detection and guiding use of sparse resources to optimize MDR-TB control. If TB is suspected, the presence of any of the above factors should alert Oromia region clinicians and public health to be screen for the MDR-TB.

Biography :

Email: girmamulisa30@gmail.com