Journal of Drug Metabolism & Toxicology
Open Access

Treating multidrug-resistant bacterial infections with bacterial viruses (Bacteriophages)

World Congress and Exhibition on Antibiotics

September 14-16, 2015 Las Vegas, USA

Andrzej G�?³rsk

Polish Academy of Sciences, Poland

Posters-Accepted Abstracts: J Drug Metab Toxicol

Abstract :

Reputed experts, international organizations and leading biomedical journals warn that the greatest risk to human health comes in the form of antibiotic-resistant bacteria. World Health Organizaton declared that the â�?�?post-antibiotic ageâ�? is on the horizon while UK chief medical officer recently pointed out that antimicrobial resistance presents a threat as grave as climate change. There has been a growing search for alternative remedies and bacteriophages (phages) have been in the center of interest. In 2005 the first center of phage therapy in the European Union was established at our Institute which has been treating patients with a wide range of bacterial infections resistant to antibiotics therapy. Our results suggest that phage therapy can achieve good results in approx. 40% of patients with untreatable infections and is very well tolerated. Phage administration may affect patientsâ�?�? immunity but its alterations are unlikely to mediate the effects observed. Although phage may elicit antibodies that can neutralize phage antibacterial activity in vitro there appears no correlation between antibody responses and the clinical outcome of phage therapy. Our recent hypothesis on phages specifically targeting infected tissues may further improve the results and open new perspectives for phage therapy.

Biography :

Andrzej Górsk is currently Vice president, at Polish Academy of Sciences, Head of Bacteriophage Laboratory, Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw and also Professor of Medicine/Immunology, The Medical University of Warsaw.

Email: agorski@ikp.pl