Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Rania Abdel Hay
Posters-Accepted Abstracts: J Clin Cell Immunol
Pityriasis Rosea is a common papulosquamous skin disease in which infective agent may be implicated, most probably due to viral infection. Innate immunity is made possible by a network of germ-line encoded pattern-recognition receptors (as Toll-Like Receptors, which detect pathogen-associated molecular patterns on invading microbes and trigger immunological responses. The aim of the work is to evaluate the role of innate immune response in Pityriasis Rosea through the detection of Toll-Like Receptors expression in the skin of affected patients. This may in turn provide a new approach to defining the disease status and may help to open up a new era in the therapeutic modalities of Pityriasis Rosea. Method: This was a case-control study that included 24 patients with pityriasis rosea and 24 normal human controls. The study was carried out to detect the expressions of TLR3, 7, 8 and 9 in the skin of these subjects by Real-time PCR. Results: The mean TLR3, 7, 8 and 9 expression level was significantly higher in patients in comparison to controls (P<0.001). There were significant negative linear correlations between TLR8 with both ESR1 and ESR2 in the patients group (r=-0.461, p=0.024 & r=-0.426, p=0.038, respectively). Conclusion: the significant elevation of TLR3, 7, 8 and 9 in cutaneous lesions of PR detected in our study, beside the detection of HHV-6 and HHV-7 DNA in PBMCs and in IgM and IgG (antibodies to HHV-6 and HHV-7), adds another proof for the viral etiology of this disease.