Journal of Clinical and Cellular Immunology
Open Access

The fabulous history of eclampsia: An update in 2017

8^th European Immunology Conference

June 29-July 01, 2017 Madrid, Spain

Pierre-Yves Robillard

Centre Hospitalier Universitaire Sud R�?©union, France

Scientific Tracks Abstracts: J Clin Cell Immunol

Abstract :

Eclampsia (together with epilepsy) being the first disease ever written down since the beginning of writings in mankind 5000 years ago, we will make a brief presentation of the different major steps in comprehension of Pre-eclampsia. 1) 1840. Rayer, description of proteinuria in eclampsia, 2) 1897 Vaquez, discovery of gestational hypertension (1 year after the invention of the inflatable arm band in 1896 by a young 31 year-old Italian physician Riva-Rocci) in eclamptic women, 3) In the 1970â�?�?s, description of the â�?�?doubleâ�? trophoblastic invasion existing only in humans (Brosens & Pijnenborg,), 4) between the 1970â�?�?s and the 1990â�?�?s, description of preeclampsia being a couple disease. The â�?�?paternity problemâ�? (and therefore irruption of immunology), 5) at the end of the 1980â�?�?s, a major step forward: Preeclampsia being a global endothelial cell disease (glomeruloendotheliosis, hepatic or cerebral vascularitis, HELLP, eclampsia), inflammation ( J.Roberts. C Redman, R Taylor), 6) End of the 1990â�?�?s: Consensus for a distinction between early onset preeclampsia EOP and late onset LOP (34 weeks gestation), EOP being rather a problem of implantation of the trophoblast (and the placenta), LOP being rather a pre-existing maternal problem (obesity, diabetes, coagulopathies etcâ�?¦). LOP is predominant everywhere on this planet, but enormously predominant in developed countries (those who publish and have the means to do research): 90% of cases. This feature is very different in countries where women have their first child very young (88% of world births), where the fatal EOP (early onset) occurs in more than 30% of cases. 7) and finally, we will approach the current stage in 2017: What is the common factor which could explain the maternal global endotheliosis in EOP and LOP?. Presentation of the inositol phosphor glycans P type.

Biography :

Pierre-Yves Robillard, neonatologist and epidemiologist. Neonatal Department Centre Hospitalier Universitaire Sud Réunion, Centre d’Etudes Périnatales Océan- Indien (Reunion island, Indian Ocean). Medical studies University of Bordeaux, fellowship in University Hospital Pointe-àPitre, Guadeloupe (French West Indies). Post-Doctoral fellowship in perinatal Epidemiology at the Medical University of South-Carolina, Charleston, SC, USA (1991-1992), International EIS course CDC Atlanta, GA, USA (1992). All his career in French overseas territories

- 16 years in Guadeloupe (French West Indies)

- 3 years in Tahiti (French Polynesia)

- 18 years in Réunion island (Indian Ocean)

Chief of the PICU-NICU in the Centre Hospitalier Universitaire Sud Réunion (2002-2015).

Co-Director of the Centre d’Etudes Périnatales Océan-Indien.

Organization since 1998 of the International Workshops on Reproductive Immunology, immunological Tolerance and Immunology of Preeclampsia. (10th Edition in 2016).

Email: robillard.reunion@wanadoo.fr