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The combined therapy «PUVA + interferon-α» in cutaneous | 3418
Journal of Clinical & Experimental Dermatology Research

Journal of Clinical & Experimental Dermatology Research
Open Access

ISSN: 2155-9554

+44 1478 350008

The combined therapy «PUVA + interferon-α» in cutaneous T-cell lymphoma treatment


5th International Conference on Clinical & Experimental Dermatology

July 13-15, 2015 New Orleans, USA

Anpilogova E M

Posters-Accepted Abstracts: J Clin Exp Dermatol Res

Abstract :

This clinical research was conducted at V.A. Rakhmanov Department of Skin and Venereal Diseases (the First Moscow State Medical University, Russia) and the Hematology Science Center (Moscow, Russia). We observed 8 patients with CTCL: 3 (37.5%) men and 5 (62.5%) women at the age of 50-56. The diagnoses were verified with histological, immunochistochemical and clonal hematological research methods. The duration of the disease ranged from 2 to 36 years. The patients had different stages of the CTCL: IA �?? 3 patients, IB �?? two patients, IIA �?? one patient, IIB �?? one patient. Before the treatment all the patients were fully examined; the contraindications for photochemotherapy were not revealed. The Hematology Science Center prescribed Reaferon (3 million units �?? 3 times per week). At the same time the photochemotherapy based on skin exposure with UV (wavelength 320-400 nm) in 2 hours after ammifurin intake (photosensitizer) was applied in our clinic. The initial dose of the irradiation depended on the phototype of the patient�??s skin and was 0.5-1.0 J/cm2. Photochemotherapy was carried out 4 times a week with gradually increasing dose of 0.5-1.0 J/cm2 in every 2 sessions to a single dose of 8-10 J/cm2. The course of therapy consisted of 20-30 procedures. After the combined therapy we reached the clinical remission in 75% of cases. The clinical behaviour was improved in 25% of cases (reduction and cessation of itching, blanching and flattering of lesions). At IA-IIA stage of CTCL the treatment was noted to be more effective.

Biography :

Catherine Anpilogova is a senior student of the Center for Innovative Methods of Education �??The Medicine of the Future�?� at the I.M.Setchenov First Moscow State Medical University. She conducts research work in close conjunction with V.A.Rakhmanov Department of Skin and Venereal Diseases. She has published more than 8 papers in reputed journals.

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