The association of EBV and vitamin D in Multiple Sclerosis patien | 3088
Journal of Antivirals & Antiretrovirals

Journal of Antivirals & Antiretrovirals
Open Access

ISSN: 1948-5964

+44 1300 500008

The association of EBV and vitamin D in Multiple Sclerosis patients with a unique cytokine signature

4th World Congress on Virology

October 06-08, 2014 Hilton San Antonio Airport, TX, USA

Sayed Mahdi Marashi

Scientific Tracks Abstracts: J Antivir Antiretrovir

Abstract :

Multiple Sclerosis is a debilitating autoimmune and inflammatory disease of the central nervous system, which is associated to both infectious and non-infectious environmental factors. We investigated the role of EBV, vitamin D status, and cytokine signature in MS patients with inflammatory complications. Molecular and serological assays were used to investigate immune biomarkers, vitamin D level, and EBV status in MS patients and sex/age matched healthy controls. EBNA-1 specific IgG antibody was examined to check the prior exposure to EBV in patients with MS and healthy controls. 98.8 % of MS patients showed a history of EBV exposure compared to 88.6 % for healthy group (p= 0.005). EBV DNA load was significantly higher in MS patients than healthy subjects (p< 0.0001). Looking at the expression levels of a panel of biomarkers, we found a distinct signature in MS patients when compared to healthy group. Indeed, the mRNA levels of CD73 and IL-17 were significantly elevated in MS patients compared to healthy group (p< 0.0001). Rather, the levels of mRNA for TGF-β, IDO, and S1PR1 were found to be significantly lower in MS patients than healthy controls (p< 0.0001). Interestingly, in MS patients, an inverse correlation was found between the concentration of vitamin D and EBV load, but not EBNA-1 IgG antibody. Our data strongly support the importance of EBV load and vitamin D status in facilitating the risk of MS development.

Biography :

Sayed Mahdi Marashi completed his PhD from University College London in 2011. His PhD project was mainly focused on functional competence of virus specific CD8 T cells in immunocompromised settings. He is currently Assistant professor of virology in Tehran University of Medical Sciences Iran.