Journal of Clinical and Cellular Immunology
Open Access

Study of chronic periodontitis in rheumatoid arthritis patients and its relation to serum ACPA levels

6^th International Conference and Expo on Immunology

October 24-26, 2016 Chicago, USA

Eiman Soliman, Ragaa Abd Elkader, Amina Hassab, Mona Helmy and Mona Ashraf

Alexandria University, Egypt

Posters & Accepted Abstracts: J Clin Cell Immunol

Abstract :

Background: Periodontitis might have a direct role in initiating and sustaining the immunoinflammatory responses in RA. Aim: To determine the prevalence of chronic periodontitis in a cohort of Egyptian RA patients and their 1st degree relatives (FDR) compared to controls and its relation to serum anticitrulinated peptides antibodies (ACPA). Materials & Methods: Group-I included 100 RA. Group-II included 50 FDR free of clinical joint disease; Group-III included 50 matched controls. DAS28 and HAQ were applied for all RA. Dental examination for all subjects including: Probing Pocket Depth (PPD), Clinical Attachment Loss (CAL), Plaque Index (PI) and Modified Gingival Index (GI). ACPA in serum was done for Groups-I and II, Group-III with periodontitis. Results: Group-I had significantly more periodontitis than II and III; a statistically significant difference between Group-I and II in PPD, CAL and PI and between Groups-I and III in PPD, CAL and PI. In group-I, 82% had positive ACPA (â�?¥20 U/ml), compared to only 8% in group II and 0% in group III. There was a significant difference in serum ACPA between Groups-I and II and I and III. Conclusion: Our study shows that individuals with RA are more likely to experience periodontitis.

Biography :

Email: solimaneiman@yahoo.com