S Narasimha Murthy
Posters-Accepted Abstracts: J Clin Exp Dermatol Res
The treatment of skin diseases using therapeutic agents requires the drug to distribute well in the skin. The dermatokinetics of drugs is the main determinant of efficacy of treatment of skin disorders. The methods of drug sampling from the dermal tissue such as biopsy sampling are blister fluid aspiration is invasive and associated with limitations and complication. Dermal microdialysis is a minimally invasive method of sampling drugs from the dermal extracellular fluid. Dermal microdialysis has been utilized in investigating bioequivalence and bioavailability studies of topical formulations. The applications, advances, limitations and future directions of dermal microdialysis technology will be discussed in this talk.