Journal of Clinical and Cellular Immunology
Open Access

Simmp sepsis (sepsis-associated persistent multiorgan immunometabolic syndrome): toward an integrative framework of immunometabolic disruption and persistent multiorgan dysfunction

2^nd International Congress on Virology, Emerging Diseases, and Vaccines

December 09, 2025 | Webinar

Jhan Sebastián Saavedra Torres

Universidad Santiago de Cali, Colombia

Scientific Tracks Abstracts: J Clin Cell Immunol

Abstract :

Sepsis is traditionally viewed as an acute condition, yet many survivors develop long-term complications that are not ex plained by the initial illness alone. This work introduces the SIMMPâ??Sepsis model (Sepsis-Associated Persistent Multiorgan Immunometabolic Syndrome), an integrative framework describing sepsis as a continuous process from acute immune ac tivation to chronic dysfunction. Based on a structured review of clinical and experimental evidence, the model outlines five interconnected levels, including persistent immune and metabolic reprogramming leading to sustained organ dysfunction and chronic clinical manifestations. Findings highlight that post-sepsis symptoms such as fatigue, cognitive impairment, dysautonomia, and recurrent infections are often under recognized. SIMMPâ??Sepsis offers a unifying perspective to support improved risk stratification, biomarker development, and precision therapies, with the potential to enhance long-term care and outcomes for sepsis survivors.

Biography :

Jhan Sebastián Saavedra Torres, MD, MSc (Clinical Immunology, Palliative Care), Specialist in Family Medicine. Research er focused on sepsis and post-sepsis syndromes, with emphasis on immunodynamic disruption, immunometabolic repro gramming, and persistent immune dysfunction. His current work integrates clinical and translational approaches to identify mechanisms of systemic vulnerability and guide personalized therapeutic strategies.