Journal of Clinical and Cellular Immunology
Open Access

Severe acute respiratory syndrome Coronavirus 2 antibodies among healthcare workers after a third dose of Vaccine in an intensive care unit

Global Summit on Vaccines and Immunology

April 19, 2022 | Webinar

Claudia Lemos, Sofia Ferreira, Filipa Corte-Real, Catarina Lume, Susana Chaves, Jose Julio, Nobrega, Claudio Gouveia, Mariana Rodrigues, Cheila Placido, Dra M Isabel, Mendonca, Jose Alves, Graca Andrade

Intensive Care Department, Hospital Central do Funchal, Funchal, Portugal
Pathology, Hospital Central do Funchal, Funchal, Portugal

Scientific Tracks Abstracts: J Clin Cell Immunol

Abstract :

The Coronavirus disease 2019 (COVID-19) and Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic emerged in China in December 2019 as a public health crisis. Healthcare workers (HCWs) are a very important high-risk group of infection and the knowledge of SARS-CoV-2 antibody seroprevalence among this class is very important, not only to evaluate the success of public health interventions but also to comprehend the spread of COVID-19 among health institutions. The objective of this prospective study was to determine the seroprevalence of COVID-19 immunoglobulin G (IgG) antibodies after the third dose of vaccine administration and assess the symptomatology associated with the number of IgG antibodies. A total of 65 HCWs from an intensive care unit were studied at one month after the third administration of the COVID-19 vaccine. They were divided into two groups: IgG antibodies greater than 15.000 (group one) and less than 15.000 (group two). There was a seroprevalence of 78.5% (group 1) and 21.5% (group 2). Group 1 consisted mainly of male individuals (68.6%), unlike group 2 which consisted mainly of female individuals (92.9%). This was statistically significant (p<0.001). We also concluded that most of group 1 had more symptoms (94.1%) and a minority of group 2 had less symptoms (14.3%), being statistically significant (p<0.001). After the administration of the vaccine, group 1 had more symptoms (p<0.001). These symptoms were myalgias (50.8%), fever (27.7%), adenopathies (35.4%), asthenia (24.6%), vomiting (12.3%), diarrhea (10.8%), chills (6.2%), epigastric pain and arthralgia (1.5%). Our study concluded that male professionals with a higher number of IgG antibodies developed the most symptoms.

Biography :

Claudia Lemos is a fourth-year intern with specific training in Intensive Care Medicine that has passion in vaccines research and clinical trials.