Reversing immunological ignorance in a mouse model of human prost | 51698
Journal of Clinical and Cellular Immunology

Journal of Clinical and Cellular Immunology
Open Access

ISSN: 2155-9899

+44 1223 790975

Reversing immunological ignorance in a mouse model of human prostate cancer

3rd International Conference and Exhibition on Clinical & Cellular Immunology

September 29-October 01, 2014 DoubleTree by Hilton Baltimore-BWI Airport, USA

Gerardo Rivera Silva

Accepted Abstracts: J Clin Cell Immunol

Abstract :

Cytotoxic T cells have the competence to attack cancer cells and eradicate a complete tumor. However, this mechanism has showed challenging for two motives. First, T cells and other elements of the immune system ignore self-molecules and cells. Second, tumor microenvironment has immunosuppressive elements capable of producing a mechanism called immunological tolerance. CD4+ T cells generate signaling molecules and activate immune cells that deliver efficient CD8+ T cell response. CD70 is essential for dendritic cells-facilitated delay of T cell tolerance initiation. CD80 and CD86 cells are implicated in the refunctionalizing the tolerized T cell. Here, these cells (CD4+, CD8+, CD70, CD80 and CD86) were obtained from a tumor prostate tissue treated with androgen ablation and were applied in a mouse model of human prostate cancer. Count cell number and purity for the particular cell population was realized by flow cytometric analysis. Preliminary results report that the activity of the CD8+T cells persisted for up to 45 days after treatment with CD4, CD70, CD80 and CD86 cells, and resulted in a significant diminution of tumor size. The stimulation of T cell infiltration and other immune cells in cancer tissues could have effects for the immunotherapeutic treatment of other hormone-related malignant tumors.

Biography :

Gerardo Rivera Silva has completed his PhD from University of Salamanca, Spain, Diploma in Molecular Biology, Pasteur Institute, Paris, and Postdoctoral studies from Laval University, Quebec and Northwestern University, Chicago. He is the Director of Laboratory for Tissue Engineering and Regenerative Medicine, University of Monterrey. He has published more than 25 papers in reputed journals and has been serving as a technical reviewer - Spanish translation- of Immunology books