Reproductive System & Sexual Disorders: Current Research
Open Access
ISSN: 2161-038X
+44 1300 500008
ISSN: 2161-038X
+44 1300 500008
Danielle Wright-Terrell
Uniformed Services University of Health Sciences, USA
Scientific Tracks Abstracts: Reprod Syst Sex Disord
The objective of this laboratory study conducted at a university hospital was to determine the effect of relugolix and elagolix on the production of extracellular matrix (ECM) proteins in human leiomyoma cells. The study used cell culture, protein analysis, and immunohistochemistry as interventions to measure the production of various proteins. The main outcome measures were the production of GnRHR, COL1A1, FN1, VCAN, p-ERK, and ERK in treated and untreated leiomyoma cells. The results showed that both drugs decreased ECM protein production and inhibited the MAPK pathway. Specifically, relugolix resulted in decreased production of COL1A1, FN1, and VCAN, while elagolix decreased the production of COL1A1 and FN1. These findings suggest that both drugs have potential therapeutic effects on leiomyoma cells and highlight their utility in being a better, long-term treatment option of abnormal uterine bleeding related to leiomyoma .
Danielle Wright-Terrell is an accomplished obstetrician and gynecologist, currently serving as an Assistant Professor at the Uniformed Services University of the Health Sciences (USUHS) in Bethesda, MD. She completed her Obstetrics and Gynecology Residency at the Medical University of South Carolina, where she also earned her Doctor of Medicine. She has published multiple articles in prestigious journals, including Fertility and Sterility Science, Military Medicine, and Cureus, and has resented her work at various conferences. Her research focuses on leiomyoma, abnormal uterine bleeding, transgender gynecology, and medical education.