Journal of Cell Signaling
Open Access
ISSN: 2576-1471
ISSN: 2576-1471
Aline Manica, Alexsandra Martins Da Silva, Andreia Machado Cardoso, Marcelo Moreno, Daniela Bittencourt Leal, Anielen Dutra Da Silva, MariaRosa Chitolina Schetinger, Vera Maria Melchiors Morsch and Margarete Dulce Bagatini
Federal University of Santa Maria, Brazil
Federal University of Fronteira Sul, Brazil
Scientific Tracks Abstracts: J Cell Signal
Statement of the Problem: The incidence of skin cancer has been globally alarming, representing a serious public health
problem, where Cutaneous Melanoma (CM), is considered the most serious due to its high metastasis capacity. In the CM
milieu, has a metabolic process deregulation with the involvement of purinergic system enzymes. Considering that, this
enzymatic chain present in all immune and vascular cells, has an important role in the control or promotion of inflammation
in tumors. Then, the aim of this work was to analyze and clarify the role of adenine nucleotides and adenosine as well as the
role of interleukins in the pathophysiology of CM and a possible mechanism of recurrence and metastasis.
Methodology & Theoretical Orientation: The samples consisted of 23 patients with CM and 23 healthy subjects. The Human
Ethics Committee of Federal University Frontier South approved the protocol under number 822.782.
Findings: Our results showed for the first time, that the inhibition of extracellular ATP hydrolysis, evidenced by significantly
decrease on purinergic enzyme activities, lead to accumulation of ATP extracellular. The presences of high ATP levels in
the post-surgery CM microenvironment suggested being the cause of deleterious changes, which are evidenced by the
uncompensated inflammatory profile. Patients with CM are treated with surgical excision, but recurrences and metastases are
common with a relapse rate between 50% and 80%. These recurrences and metastases can be the result of changes that remain
even after its removal.
Conclusion & Significance: The modifications observed in this study may reflect the CM microenvironment alterations,
whereas, after removal of the tumor, they can represent high CM aggressiveness. Besides this understanding, the interaction
between tumor cells and the immune suppression of anti-tumor immunity will help provide insights that will allow the
introduction of future novel therapeutic approaches for the management of patients with melanoma.
Aline Manica has her expertise in biochemistry and metabolic and oncological diseases. Her work shows the changes caused by this cancer that can remain even after surgical removal, especially by the inflammatory profile, which are being in favor of relapses and metastases. The data’s demonstrated in her study will help provide insights that will allow the introduction of future therapeutic approaches for the management of patients with melanoma.
E-mail: alinemanica@yahoo.com.br