Journal of Drug Metabolism & Toxicology

Journal of Drug Metabolism & Toxicology
Open Access

ISSN: 2157-7609


Protective effects of a poly herbal formulation against aspirin induced ulcers in Wistar rats

International Conference on Toxicogenomics and Drug Monitoring

August 25-27, 2015 Valencia, Spain

G Balaji

Clintox Bio Services, India

Posters-Accepted Abstracts: J Drug Metab Toxicol

Abstract :

The poly herbal formulation has been used traditional in folk medicine due to its antiseptic, astringent and antifungal property. The formulations are rich in tannins and have been proved experimentally to possess antibacterial, wound healing and antiulcergenic effects. The present investigation was designed to determine the gastro protective effect of Polyherbal Formulation (PHF) at a dose of 150 mg/kg in a model of aspirin induced ulcers in rats and to study the mechanism involved using H2 receptor blocker Ranitidine as comparison. In treated groups of animals the in vivo antioxidant levels such as SOD, CAT, and Glutathione levels was increased and LPO levels was decrease and found more or less equal to the normal values. The histopathological examinations of the stomach of the ulcerated animal��?s show severe erosion of gastric mucosa, submucosa edema and neutrophil infiltration. These results suggest that the gastroprotective effects of PHF in this experimental model through antioxidant and cytoprotective activity.