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Primary cutaneous T cell lymphomas: Photochemotherapy immunomodul | 13179
Immunome Research

Immunome Research
Open Access

ISSN: 1745-7580

Primary cutaneous T cell lymphomas: Photochemotherapy immunomodulation with analysis of the inflammatory expansive cellular dynamic


11th Annual Congress on Immunology & Immunotechnology

September 13-14, 2018 | Zurich, Swizerland

Luiz Werber-Bandeira

Santa Casa de Misericordia Hospital, Brazil

Keynote: Immunome Res

Abstract :

Primary cutaneous T cell lymphomas (CTCLs) are characterized by hyperproliferation of malignant CD4+ T cells with primary localization on the skin. The common characteristics are the migration of the malignant mature T-lymphocytes into the epidermis, with hyperproliferation of malignant CD4+ T cells and epidermotropism. S├ęzary syndrome (SS) is the leukemic variant. It was established that CTCLs arise from a clonal expansion of CD4+ T cells with an identical rearrangement of the T cell receptor. The purpose of this study was to evaluate the immunomodulation effect of photochemotherapy-A (psoralen plus ultraviolet A (PUVA)). Pre- and post-PUVA punch skin biopsies of nine patients were stained immunohistochemically for CD34+, CD8+, CD7+, CD16+, CD56+, CD1a+, Bcl2+, p53+, CD45RA+, and CD45RO+ cells. The results showed a pre-PUVA cells/mm2 without significant difference among expansive or reactive cells. Post-PUVA analysis showed a significant decrease in the mean of expansivereactive cells. PUVA was immunomodulated decreasing cellular infiltrate. These findings could contribute to the comprehension of how PUVA acts. We achieved ectoscopic clearance of the lesions, although post-PUVA, there still was a mononuclear pathological infiltrate. This result demonstrates that the PUVA treatment should only be withheld when the histological analysis is normal.

Biography :

Luiz Werber-Bandeira is the Head of Clinical and Experimental Immunology Unit - Santa Casa de Misericórdia do Rio de Janeiro, Brazil. He has a degree in Medicine; completed his Post-doctorate in Immuno-Genetics and; PhD in Medicine-Immunology-Dermatology at Federal University of Rio de Janeiro.For 36 years in the profession, he has done Post-Doctorate in Immuno-Genetics from the Oswaldo Cruz Foundation (FioCruz-RJ), a master's degree and a PhD from the Federal University of Rio de Janeiro (UFRJ). He is coordinator of the Postgraduate Course in Immunology and Clinical and Laboratory Allergy, organizer responsible for the Research Line of the Clinical and Experimental Immunology Unit of the Santa Casa da Misericórdia in Rio de Janeiro, as well as a professor who participates in the line of research in PhotoDermatology and Immunology of UFRJ. Dr. Luiz Werber-Bandeira was awarded by the City Council of Rio de Janeiro for services rendered to Continuing Medical Education in Medicine-Immunology with the Pedro Ernesto Medal.

E-mail: werberbandeira@globo.com

 

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