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Prevalence of non typhoidal Salmonella among HIV patients attendi | 34294

Applied Microbiology: Open Access
Open Access

ISSN: 2471-9315

+44 1300 500008

Prevalence of non typhoidal Salmonella among HIV patients attending Federal Medical Centre, Ido Ekiti, Nigeria


4th World Congress and Expo on Applied Microbiology

September 19-21, 2016 Las Vegas, USA

Fatoba Johnson Sunday

Ekiti State University, Nigeria

Posters & Accepted Abstracts: Appli Micro Open Access

Abstract :

Non Typhoidal Salmonella (NTS) is an important opportunistic zoonotic pathogen among immunocompromised patients, especially those infected with the Human Immunodeficiency Virus (HIV). This study was therefore carried out to determine the prevalence and antibiotic resistance of NTS among HIV patients in the era of highly active antiretroviral therapy (HAART). A total of 107 stool samples were collected and cultured on bismuth sulfite agar after enrichment in selenite fecal. Bacteriological and biochemical tests were carried out using standard procedure. The CD4+ count was determined using dual-platform flow cytometry. Relevant information was obtained from the patients using a questionnaire. Of 107 patients, 64 were females (60%) and forty-three (40%) were males. Forty-seven (44%) of the patients were in the age group of 21-30 years. Of the patients examined; 42 (39.1%) were businessmen and women while the rate of isolation of NTS was higher among civil and public servants having 33.3%, source of drinking water for 69% of the patients were well water. Seventeen (28.3%) of those who drank from well water yielded positive growth of NTS. Of the 62 (58%) patients on HAART, 32 (52%) had a CD4+ count above 300 cells/�?¼l, three (39.1%) of them yielded positive growth of NTS. Of the 45 patients who were without HAART, 13 (9.4%) had a CD4+ count less than 200 cells/�?¼l, eleven yielded growth. Statistical analysis showed that there was no significant difference between the antibiotic resistance of NTS isolated from HIV patients on HAART and those without antiretroviral therapy. The NTS isolated exhibited 100% resistance to each of penicillin, ofloxacin and ciprofloxacin. Resistance to ceftazidine and gentamycin was 65% and 62% respectively. All the twenty-one NTS isolated from HIV patients in this study exhibited multiple resistances to all antibiotics tested. In conclusion, the high level of multiple antibiotic resistances observed in NTS isolated from HIV patients may likely jeopardize the effectiveness of the treatment of this bacterial infection in them.

Biography :

Email: Fatobajohnson07@gmail.com

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