Persistence of pathogenic for man hantaviruses in Apodemus mice p | 5703
Journal of Antivirals & Antiretrovirals

Journal of Antivirals & Antiretrovirals
Open Access

ISSN: 1948-5964

+44 1300 500008

Persistence of pathogenic for man hantaviruses in Apodemus mice populations

5th World Congress on Virology

December 07-09, 2015 Atlanta, USA

Tatyana Kushnareva

G P Somov Research Institute of Epidemiology and Microbiology, Russia

Posters-Accepted Abstracts: J Antivir Antiretrovir

Abstract :

Objective: Complex monitoring of dynamics of epizootic and epidemic processes on HFRS endemic areas in Primorye Region of Far East Russia with the purpose of evaluation persistence of Hantaan (genovariant FE) and Amur hantaviruses and detection of periods of acute infection in theirs rodent-reservoir populations ��? Apodemus agrarius and A. peninsulae accordingly were performed. Methods: Epizootological monitoring was carried out in the forest-steppe landscape favourable for A. agrarius and in the cedar-oak forests optimum for A. peninsulae (2001-2013). Criteria of acute infection were detection of viral antigen/RNA in the lungs and organs of secretion/excretion and low avidity antibody in blood of rodents using ELISA, RT-PCR and IFA. Cases of HFRS diseases were summed in every epidemic season. Results: The specific antigen/RNA in eliminative organs were detected of 2.0% A. agrarius and 1.6% A. peninsulae in period of epizootic activity increase and 1.8% and 9.6% respectively during high epizootic activity. Period of low epizootic activity in different Apodemus mice populations was associated with 0.2% A. agrarius and 0.7% A. peninsulae with acute infection. In year of high activity of epizootic process seasonal dynamic of hantaviral infection in A. agrarius populations was characterized by increase of infected mice from spring (3.5%) to autumn (13.4%) and on the contrary by decrease in A. peninsulae populations (18.1% and 4.0% respectively). Animals with hantaviral antigen in eliminative organs were mainly at 3-5 months old and 67.4% from them had low avidity IgG antibodies. Annual variations of epidemic activity of different HFRS natural foci directly correlated with numbers of carriers of acute hantaviral infection in A. agrarius and A. peninsulae populations. Conclusion: Outbreaks of HFRS on Primorye Territory were observed at the same year of high epizootic activity in hantaviral infection natural foci. Thereby, we can conclude that periods of acute infection in Apodemus mice populations cause increase of HFRS morbidity.

Biography :

Tatyana Kushnareva is the leading Researcher in Hantaviral Infections Laboratory in Institute of Epidemiology and Microbiology, Vladivostok, Russia. She is the executive of the section of basic researches on disclosure of hantavirus circulation mechanisms in the nature and regularities of natural foci functioning in various landscape, development and improvement of forecasting methods of HFRS incidence on endemic territories. She is directly involved in carrying out the epizootological researches in the field conditions in natural foci. Within the last five years she published 48 works: 13 in reviewed magazines, 30 in periodic scientific publications and conference materials, 4 databases, and methodical recommendations.