Journal of Drug Metabolism & Toxicology
Open Access

Patterns of antibiotic susceptibility of urinary tract infection-causing bacteria in general hospital in Lithuania

3^rd World Congress and Exhibition on Antibiotics and Antibiotic Resistance

July 31-August 01, 2017 | Milan, Italy

Gintautas Gumbrevicius, Evelina Magelinskaite, Simona Stankeviciute and Vaidotas Galaune

Lithuanian University of Health Sciences, Lithuania

Posters & Accepted Abstracts: J Drug Metab Toxicol

Abstract :

Statement of the Problem: Urinary Tract Infections (UTIs) are some of the most common infectious diseases. Rapidly rising antibiotic resistance among uropathogens is one of the main problems in treating UTIs. There is little data about the antibiotic susceptibility patterns of UTI-causing bacteria in Lithuania. The purpose of this study was to determine the susceptibility patterns of UTI-causing bacteria, and to assess the possible factors that influence resistance to antibiotics. Methodology: Details of bacteria grown from 149 urine samples was collected and analyzed from December 2015 to February 2016. Results: The most commonly isolated uropathogen was Escherichia coli (47.65%), followed by Klebsiella pneumoniae (20.13%), Enterococcus spp. (11.11%) and Proteus spp. (8.47%). E. Coli isolated from urine samples was resistant to ampicillin (52.11%), ciprofloxacin (28.17%) and trimethoprim (26.76%), while K. pneumoniae showed high resistance rate to nitrofurantoin (83.33%), ampicillin/sulbactam (80.00%) and cephalosporins (76.67%). Enterococci showed frequent resistance to trimethoprim (71.43%), ciprofloxacin (57.17%) and ampicillin (42.86%), Proteus spp. demonstrated frequent resistance to nitrofurantoin (76.92%), trimethoprim/sulfamethoxazole (61.54%) and ampicillin (46.15%). All E. Coli, Enterococcus spp., Proteus spp. and K. pneumoniae isolates were susceptible to imipenem and meropenem, and all enterococci were susceptible to linezolid. In patients who had previously taken fluoroquinolones, aminopenicillins, cephalosporins and trimethoprim/sulfamethoxazole, E.Coli showed significant higher resistance rate to antibiotics. In patients with nosocomial UTIs, E. Coli displayed significantly higher resistance to ciprofloxacin, gentamicin and ampicillin than patients with community-acquired UTIs, the same pattern was observed in Enterococcus spp. resistance to vancomycin. Conclusion & Significance: Alarmingly high rates of antibiotic resistance were observed among the most common uropathogens. It is necessary to periodically investigate antibiotic resistance and frequently adjust treatment recommendations according to the collected data.

Biography :

Email: stanksim@gmail.com