Journal of Clinical and Cellular Immunology
Open Access

Pathogen recognition receptor pathways are disrupted in the chronic hepatitis-B

Conference Series LLC Joint International Event on 5^th European Immunology & Innate Immunity

July 21-23, 2016 Berlin, Germany

Mohammad Kazemi Arababadi

Rafsanjan University of Medical Sciences, Iran

Posters & Accepted Abstracts: J Clin Cell Immunol

Abstract :

Introduction: Pathogen recognition receptors (PRRs) play key roles in innate immunity against viral infections. It has been also demonstrated that the patients with chronic hepatitis-B (CHB) are unable to eradicate HBV from hepatocytes. It has been hypothesized that innate immunity dysfunction may be considered as a main candidate for specific disrupted immune responses against HBV in the CHB patients. Accordingly, our research team have been evaluated the expression levels of TLRs, TLRs signaling molecules (MYD88, TRIF, IRAK1, TRAF6, IRAK4, TRAF3, NF-�?�?�?ºB and IRF7), inflammasomes (NLRP1, NLRP3, NLRC4 and AIM2), inflammasomes downstream molecules (ASC and Caspase-1), MDA5 and RIG-1 in CHB patients. Material & Methods: This study was performed on 60 CHB patients and 60 healthy controls and the expression levels of the molecules were evaluated by Real-Time PCR technique. Results: The results demonstrated that expression levels of TLR9 and its intracellular signaling molecules, MDA5, ASC, Caspase-1 and NLRP3 were significantly decreased in PBMCs of CHB patients in comparison to healthy controls. Conclusion: Based on the results presented here it seems that CHB patients do not express appropriate levels of PRRs in several pathways which may lead to impaired immune responses against HBV infection which is seen in the patients.