Journal of Antivirals & Antiretrovirals
Open Access

Oral plasmablastic lymphoma: Recent concepts in molecular diagnosis

International Conference and Exhibition on VIROLOGY

5-7 September 2011 Baltimore, USA

Sachin Sarode

Scientific Tracks Abstracts: JAA

Abstract :

Oral Plasmablastic lymphoma (PBL) is a rare, recently described B-cell derived non- Hodgkin�s lymphoma, commonly seen in patients with HIV infection. It usually shows plasmablastic morphology with expression of plasma cell-associated antigens and weak or no expression of B-cell associated markers. Most of the cases show monoclonal rearrangement of the immunoglobulin heavy chain gene (IgH) and/or clonal restriction of Ig light chain (IgL) gene expression. An etiological role for EBV seems likely but the association with HHV8 is questionable. It is characterized by a diagnostic triad of predilection for gingivo-buccal complex mucosa, classical plasmablastic morphology with the lack of neoplastic plasma cells and a limited immunohistochemical panel. Th e treatment guidelines for PBL are not well defi ned and patients have been treated heterogeneously with chemo and/or radiotherapy, although the prognosis is poor. Th e present paper discusses the epidemiological, clinical, immunohistochemical aspects of almost all the reported cases of oral PBL in English medical literature with special emphasis on the recent concepts in molecular diagnosis.