Neuroprotective effect of compound K isolated from fermented Korean Ginseng through stimulation of Nrf2 signaling pathway
Medicinal & Aromatic Plants

Medicinal & Aromatic Plants
Open Access

ISSN: 2167-0412

Neuroprotective effect of compound K isolated from fermented Korean Ginseng through stimulation of Nrf2 signaling pathway

Global Summit on Herbals & Natural Remedies

October 26-27, 2015 Chicago, USA

Jong-Sang Kim

Kyungpook National University, South Korea

Posters-Accepted Abstracts: Med Aromat Plants

Abstract :

Ginseng, a traditional herbal medicine, has been extensively used in Korea and other East Asian countries for millenniums to maintain physical vitality, boost immune system, and delay aging process. It has been processed into various kinds of dietary supplement and alternative medicine with booming market demands. Ginseng and its products account for major portion in √ʬ?¬?Health Functional Foods√ʬ?¬? market in Korea. Compound K (20-O-(b-D-glucopyranosyl)-20(S)-protopanaxadiol) is a major ginsenoside metabolite detected in the urine and blood of rats after Ginseng administration. As compound K was reported to have antiinflammatory and anti-oxidative activities, we hypothesized that it could exert neuroprotective action. Compound K significantly reduced cytotoxicity and Reactive Oxygen Species (ROS) generation induced by glutamate in HT22 cells, whereas it did not restore glutathione depletion caused by glutamate. In addition, it was further investigated whether compound K affected the expression of Heme Oxygenase (HO)-1, one of the major cellular antioxidant defense systems, and it was found that it dose-dependently increased HO-1 expression. Compound K-mediated cytoprotection of HT22 neuronal cells from glutamate insult was abrogated by either HO-1 inhibitor (Tin protoporphyrin, SnPP) or AKT inhibitor (LY294002). In conclusion, the present results demonstrate for the first time that compound K protects neuronal cells against glutamate-induced oxidative injury through the induction of HO-1 expression, which is, in turn, activated maybe through Nrf2-Keap1 and PI3K/AKT signaling pathways.

Biography :

Jong-Sang Kim completed his PhD from University of California at Berkeley in 1991 and Postdoctoral training for 1 year in the same campus. He is the Tenured Full Professor of School of Food Science and Biotechnology, Kyungpook National University. He has published more than 180 papers in peer-reviewed international journals and has been serving as a Senior Editor of Food Science and Biotechnology, a SCI journal.

Email: [email protected]