Medicinal & Aromatic Plants
Open Access
ISSN: 2167-0412
ISSN: 2167-0412
A V Yadav and C D Upasani
Savitribai Phule Pune University, India
Posters & Accepted Abstracts: Medicinal Plants
Nephrotoxicity is a dose-dependent side effect of cisplatin that limits its clinical utility. The protective effect of hydroalcoholic extract of Plumeria Rubra (PR) was studied against Cisplatin (CP) induced nephrotoxicity in rats. PR was administered orally at 3 dose levels (100, 200 and 400 mg/kg). Vitamin E (250 mg/kg) was used as standard nephroprotective agent. The kidney function test (estimation of serum creatinine, albumin, blood urea nitrogen [BUN]), oxidative stress study (estimation of superoxide dismutase [SOD], malondialdehyde [MDA]) activity and histological examination of kidneys was conducted. The efficacy of PR was compared with CP treated group. The elevation in these serum biomarkers of renal damage, oxidative stress were significantly restored towards normal in PR treated groups. Additionally, histopathological examination of kidneys showed that PR markedly ameliorated CP induced renal tubular necrosis. PR was found effective at all doses, although high dose (400 mg/kg) was found to be more effective and comparable with standard group (Vitamin E 250 mg/kg). Present investigation revealed that PR resulted in dose dependent attenuation of CP induced renal damage in rats.