Journal of Glycomics & Lipidomics
Open Access

N-3 Docosahexaenoic Acid (DHA) status is positively associated with plasma lipocalin and resistin and inversely associated MCP-1 in post-partum women

International Conference on Lipid Science & Technology

November 30 - December 02, 2015 San Francisco, USA

Mary A Harris, Wesley Pendleton and Kimberly Cox-York

Colorado State University, USA

Posters-Accepted Abstracts: J Glycomics Lipidomics

Abstract :

DHA is an omega-3 fatty acid with demonstrated anti-inflammatory and potential insulin-enhancing and anti-obesity effects. This study examined the relationship of DHA with Lipocalin II, a ligand for small lipophilic substances which presumably participates in inflammation. We previously demonstrated a seemingly paradoxical positive association between erythrocyte (RBC) n-3 DHA and lipocalin II in 85 pregnant women at 24 ��? 26 weeks of gestation. A follow up study of 27 of these participants at 1.5 ��? 2 y postpartum (mean age 35 +/- 3.7 y, BMI 24.6 +/- 3.5) supplemented with 0 or 300 mg DHA from week 26 of pregnancy through three months of lactation, reaffirmed the positive correlation between RBC-DHA (expressed as % total fatty acids) and lipocalin (r=0.451, p=0.018). RBC n-3 DHA and total dietary intake of DHA were positively correlated with the anti-inflammatory adipokine, resistin (p=0.031) when corrected for BMI. RBC DHA was negatively correlated with the inflammatory mediator MCP-1 (r=-0.427, p=0.026).

Biography :

Email: mary.harris@colostate.edu