Multivariate analysis of factors associated with the koebner phen | 9505
Journal of Clinical & Experimental Dermatology Research

Journal of Clinical & Experimental Dermatology Research
Open Access

ISSN: 2155-9554

+44 1478 350008

Multivariate analysis of factors associated with the koebner phenomenon in vitiligo: An observational study of 381 patients

14th International Conference on Clinical and Experimental Dermatology

June 19-20, 2017 Philadelphia, USA

Huma Khurram

King Saud University, Saudi Arabia

Posters & Accepted Abstracts: J Clin Exp Dermatol Res

Abstract :

Background: The Koebner phenomenon (KP) is a common entity observed in dermatological disorders. The reported incidence of KP in vitiligo varies widely. Aim: To estimate the prevalence of KP in vitiligo patients and to establish different associations between KP and vitiligo characteristics. Methods: A cross-sectional observational study was conducted using 381 vitiligo patients. Demographic and clinical information was obtained via the completion of Vitiligo European Task Force (VETF) questionnaires. Patients with positive history of KP were extracted from this vitiligo database. Multivariate analysis was performed to assess associations with KP. Result: The median age of cases was 23 years (range=0.6-76). In total, 237 of the patients were male (62.2%). Vitiligo vulgaris was the most common type observed (152/381, 40%). 72% (274/381) patients did not exhibit KP, whereas 28.1% (107/381) of patients exhibited this condition. Age (p=0.019), BSA% (p<0.001) and disease duration (p=0.011) were significantly increased in cases with KP compared with cases without KP. Family history of vitiligo, leukotrichia, halo nevi and premature grey hair were not significantly associated (p>0.05) with KP. KP was more common in males 64/107 (59.8%, p=0.004). Progressive disease (OR = 1.82, CI (1.17 ��? 2.92), p=0.041), > 5 years disease duration (OR = 1.92, CI (1.22 ��? 2.11), p=0.003) and BSA > 2% (OR = 2.20, CI (1.26 ��? 3.24), p<0.001) were significantly associated with positive KP. Conclusion: Our results suggest that KP may be used to evaluate disease activity and investigate different associations between the clinical profile and course of vitiligo. Future studies are needed to predict the relationship between KP and responsiveness to therapy.

Biography :