Journal of Cancer Research and Immuno-Oncology
Open Access
ISSN: 2684-1266
ISSN: 2684-1266
Eva Falomir
Jaume I University, Spain
Scientific Tracks Abstracts: J Cancer Res Immunooncol
Fourteen triazole derivatives have been developed using simply synthetic strategies. The structures were designed by docking studies based on previous results to target both PD-L1 and VEGFR-2 and, also the effect on oncogene c-Myc was studied. The antiproliferative activity on monocultures of several tumor cell lines (HT-29, A-549 and MCF-7), and on other human cell lines as HEK-293 was studied. Then, the effect on anticancer targets (PD-L1, VEGFR-2 and c-Myc) was determined. Later, the effect on cancer cell viability when co-cultured with immune cells (Jurkat T cells or THP-1) was also studied. And, finally, the potential antiinflammation action was determined by measuring the effect of some selected compounds on IL-6 secretion to cell media in monocultures of cancer and immune cells and in cocultures of both types of cells.
Dr. Eva Falomir studied Chemistry at the Valencia University, Spain and graduated as MS in 1994. She then joined the research group of Prof. Carda at Jaume I University (UJI). She received her PhD degree in 1998 at the same institution. After two years postdoctoral fellowship supervised by Dr A. Fürstner at Max-Planck Institute, Germany she obtained the position of an Associate Professor at UJI. In 2022, she got a Full Professor position in the same university. She has published more than 100 research articles in SCI(E) journals.