Journal of Antivirals & Antiretrovirals
Open Access

Mother-to-child HIV transmission and its predictors among HIV-exposed infants: A retrospective follow-up study in Southwest Ethiopia

2^nd International Conference on Retroviruses and Novel Drugs

June 30-July 01, 2016 Cape Town, South Africa

Mulu Mulualem Tadesse

Belay Birlie, Tadele Akaba , Kibrealem Sisay, Abdisa Gurmessa, Dinberu Seyoum.
Department of Medical Laboratory Sciences and Pathology, College of Health Sciences, Jimma University, Jimma, Ethiopia

Posters & Accepted Abstracts: J Antivir Antiretrovir

Abstract :

Despite the marked progress in coverage of prevention of mother to child HIV transmission (PMTCT) programs, high rate mother to child HIV transmission (MTCT) was documented. This raised questions about the effectiveness of PMTCT program and the need for more research on identifying predictors of MTCT of HIV. A retrospective follow up study was carried at Jimma University Specialized Hospital PMTCT clinic to quantify MTCT rate and its predictors among HIV-exposed infants. Data were extracted from medical records of HIV-infected women and exposed infants between September 2010 and December 2012. Univariate and multivariate logistic regression analyses were carried out to identify potential infant and maternal factors predicting mother to child HIV transmission. A total of 146 infants born to HIV-infected mothers were included in the analysis. Out of 146 infants, 25 (17%, 95% CI: 11%- 23.2%) were HIV positive. In the adjusted multivariate logistic regression analysis, mothers on late AIDS stage (stage 3 or 4) during child birth (OR=5.8; 95% CI: 1.6-16.5), absence of maternal PMTCT interventions (OR=4.9; 95% CI: 1.4-16.5), home delivery (OR=8.1; 95% CI: 2.1-31.9) and mixed infant feeding (OR=5.6; 95% CI: 1.4-41.2) were independently associated with mother to child HIV transmission among exposed infants. We documented a high rate of mother to child HIV transmission among exposed infants in Southwest Ethiopia. All pregnant HIV positive mothers should receive antiretroviral therapy at earlier stage. In addition, delivery at health center and exclusive breast feeding should be encouraged so as to decrease mother to child HIV transmission.

Biography :

Email: mulualemt.tadesse@gmail.com