Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Jamal
Posters-Accepted Abstracts: J Clin Cell Immunol
Pigeon fanciers lung (PFL) is a form of extrinsic allergic alveolis (hypersensitivity pneumonitis) the pathogenesis of the disease is through to be cased by the deposition of immune complexes in the alveoli. Although this is generally agreed in the bionic pathogenesis of disease it is difficult to understand why a large proportion of people with high titres of antibody do not get disease. In this study I firstly showed the optimal concentration of LPS and the optimum time for activation was 10 μ/ml for 24 hours after stimulated the cells by PMA for 72 hours. Immune complexes were generated with mucin, fresh pigeon droppings (PDF), old pigeon droppings (PDO), and patents sera. Immune complexes with PDF and PDO activated macrophages to produce TNFα. However immune complex with mucin did not active macrophages. There was different in the ability of immune complexes from symptomatic and asympomatic individual to activation macrophage.