Journal of Drug Metabolism & Toxicology
Open Access

Lipase-catalyzed synthesis of a functional xylitol ester of 7, 10-dihydroxy-8(E)-octadecenoic acid

Joint Event on 31^st Euro Global Summit and Expo on Vaccines & Vaccination & 4^th World Congress and Exhibition on Antibiotics and Antibiotic Resistance

June 14-16, 2018 Barcelona, Spain

Yeon-Jung Lee, Ji-Sun Moon, Hyung-Geun Lee, Ching T Hou and Hak-Ryul Kim

Kyungpook National University, South Korea
National Center for Agricultural Utilization Research,

Posters & Accepted Abstracts: J Drug Metab Toxicol

Abstract :

Hydroxy fatty acids have been widely studied because they have various biological properties that can be utilized in many industries, compared with other types of fatty acids. Among the hydroxy fatty acids, our research group focused on 7, 10-dihydroxy-8(E)-octadecenoic acid (DOD). We confirmed that the strong antibacterial activities of DOD against foodborne pathogenic bacteria and plant pathogenic bacteria. Saccharideâ�?�?fatty acid esters are important biodegradable emulsifiers in foods, cosmetics, and pharmaceuticals; hence, we focused on enzymatic synthesis of DOD-saccharide esters for industrial utilization of DOD. Several saccharides were screened as substrates for esterification with DOD. As a result, DOD xylitol ester was successfully produced at 50�?ºC with stirring at 200rpm for 24 hours in the presence of lipozyme RMIM as enzyme, and t-butyl alcohol as solvent. Its structure was confirmed by GC/MS. yeon2g@knu.ac.kr