Journal of Antivirals & Antiretrovirals
Open Access

Large scale sequencing in samples of individuals recently infected with HIV and those with late diagnosis

5^th World Congress on Virology

December 07-09, 2015 Atlanta, USA

Shirley Komninakis, Santana L C, Arnold R, Lopes R, C�­cero M, Mantovani N, Ara�ºjo P and Diaz R S

Federal University of S�£o Paulo, Brazil

Posters-Accepted Abstracts: J Antivir Antiretrovir

Abstract :

With the advent of Highly Active Therapy (HAART) for the treatment of HIV-infected individuals was the emergence of resistant viral majority and minority populations selected by selective pressure. Despite the monitoring of resistance mutations ARVs, there is insufficient data related to transmitted resistance and polymorphisms caused by drugs used to treat rescue. The aim of this study was to evaluate through large-scale sequencing the occurrence of transmitted resistance mutations (TDRM). Of the 19 sequenced samples were evaluated 10 individuals with late diagnosis and four recent infection of HIV-1. Polymorphisms were found in all sequences evaluated for the protease gene (PR), reverse transcriptase (RT) and integrase (IN). The frequency of mutations can be seen in the chart below. Our results showed that in patients with recent infection (infected at least 180 days) there are viral populations HIV who carry mutations to all classes of drugs particularly the NNRTIs in contrast to those with late diagnosis.

Biography :

Email: skomninakis@yahoo.com.br