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Investigation of antifungal activity of Leptadenia pyrotechnica f | 44741
Medicinal & Aromatic Plants

Medicinal & Aromatic Plants
Open Access

ISSN: 2167-0412

+44 1300 500008

Investigation of antifungal activity of Leptadenia pyrotechnica from Pakistan


5th International Conference & Exhibition on Herbal & Traditional Medicine

November 05-06, 2018 | London, UK

Mehmooda Munazir, Rahmatullah Qureshi, Muhammad Gulfraz and Asma Ahmad

GC Women University, Pakistan
PMAS-Arid Agriculture University, Pakistan
COMSATS University, Abbottabad Campus, Pakistan
University of Lahore, Pakistan

Posters & Accepted Abstracts: Med Aromat Plants

Abstract :

Most of the fungal species become seriously life threatening pathogens in patients with immuno-suppressed immune system. Aspergillus fumigatus and A. niger are among such fungi. The number of reports on antifungal drug resistance is increasing day by day from various parts of globe. This situation calls for search of novel antifungal agents. In the present research work, root and aerial parts of a native desert plant Leptadenia pyrotechnica was tested for their antifungal activity against A. fumigatus and A. niger. A total of eight solvents including n-hexane, chloroform, acetone, ethylacetate, butanol, ethanol, methanol and water were used for extraction based on differences in polarities. The different concentrations of extracts ranging from 10 mg/ml to 50 mg/ml were tested against both microbes. The highest growth inhibition was observed at a concentration of 50 mg/ml. Only ethylacetate and ethanolic extracts of roots were active against A. niger with ZI of 9±1.53 mm (Activity index=0.45) and 8±0.577 mm (AI of 0.69) respectively. In the case of A. fumigatus, ethanolic and methanolic extracts were active with ZI of 8±0.577 (AI=0.44) and 12±2.0 (AI= 0.50). While in case of aerial parts, only ethylacetate extract could inhibit the growth of A. niger and A. fumigatus with ZI of 8±0.2 mm (AI= 0.58) and 8±0.577 mm (AI of 0.53) respectively. These results indicated that ethanolic extract of roots of L. pyrotechnica had highest activity which can be investigated further for potential compounds with antifungal activity.

Biography :

Mehmooda Munazir has completed her PhD at PMAS-Arid Agriculture University Rawalpindi, Pakistan. She is serving as an Assistant Professor in the Department of Botany at GC Women University, Sialkot since 2015. She has published nine articles, out of which seven carry impact factor. She is a Reviewer of two reputed international journals and NAYS e-magazine project of NAYS (National Academy of Young Scientists), Pakistan. She has served as Deputy Director, Quality Enhancement Cell and as Manager, University-Industry Linkages at GC Women University Pakistan.

E-mail: mehmooda.munazir@gcwus.edu.pk

 

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