Pancreatic Disorders & Therapy
Open Access
ISSN: 2165-7092
ISSN: 2165-7092
Georg S Kobinia and Ruiz-Navarro F
Austrian Society for Regenerative Medicine, Austria
Posters & Accepted Abstracts: Pancreat Disord Ther
Background: Type1 diabetes (T1D) is an autoimmune destruction of islet �?²-cell. Recent studies have shown that cell therapy is promising. Objective: To study safety and efficacy of direct transgastric intrapancreatic (DTI) transplantation of Autologous Bone Marrow-Derived Mononuclear Cells (A-BMMNCs) as a potential treatment for Egyptian patients with T1D. Method: 17 patients between 2 and 30 years were assigned to receive a single treatment of A-BMMNCs through DTItransplantation and follow up for 1 year. Main outcome is to assess safety. Then, measure fasting and postprandial 2-hour C-Peptide levels (FCP, 2h-CP) , glycated hemoglobin (HbA1C), and insulin and islet cell antibody if serologically positive to assess �?²-cell function. Results: Islet cell antibody was undetectable before the transplantation for all patients. 6 out of 10 positive patients convert to negative insulin antibody within one year; remaining patients were negative insulin antibody. FCP significantly rise up in the first 2 months, little change in 2h-CP, decrease HbA1C and insulin doses until the first 5 months post-transplant in compared with before (Pâ�?¤0.05). No complications were recorded until complete the study for all patients. Conclusion: A-BMMNCs by DTI technique is a simple and safe innovative procedure. It can temporarily modify course of T1D. It could be beneficial in the future as a treatment modality to control the progression and it may open a new way to cure diabetes