Manoj Kumar1, D N Rao2, Sujata Mohanty3, Arul Selvi4 and Sanjeev K Bhoi1
Posters-Accepted Abstracts: J Clin Cell Immunol
Background: Trauma injury and hemorrhagic shock frequently leads to the imbalance of immune system known as Systemic Inflammatory Response Syndrome (SIRS) and is connected to the morbidity or mortality. Pro and Anti-inflammatory, which play a significant role in the development of multiple organ failure (MOF). Objective: This study investigates the serum cytokines levels in patients with trauma hemorrhagic shock and the association of these cytokines with clinical outcome. Design: Prospective cohort study Patients: A total 70 patients with trauma hemorrhagic shock admitted to the emergency department, level 1trauma centre. Method: Peripheral blood samples were collected in each patient for determination of serum cytokines concentration. Samples were obtained within 8 h of post injury with T/HS patients. Standard resuscitation techniques as per Advance Trauma Life Support were used in each patient. Clinical and laboratory data were prospectively collected. Results: High concentrations of circulating IL-6, IL-10, IL-8, IL-12, (p< 0.05) were detected in a trauma hemorrhagic shock as compared with healthy control group. At study entry, IL-8 concentrations were higher in non-survivors as compared with survivors T/HS patients but not TNF-?, IL-1 ?, IL6, IL10. Increased IL-8 value was an indicator of mortality in patients with trauma hemorrhagic shock. Conclusions: In trauma hemorrhagic shock, increased IL-6, IL-10, IL-8, IL-12 are detected while compared to normal healthy control. In these patients, increased IL-8 value in nonsurvivors as compared to survivors and TNF-?, IL-1 ?, IL6, IL10 do not correlate with clinical outcome. This study suggests a much higher degree of activation of immune-inflammatory in T/HS than in normal healthy control. Increased IL-8 values were found to be reliable markers of mortality following T/HS.