Journal of Antivirals & Antiretrovirals
Open Access

Interaction between the transcriptional machineries in pseudorabies virus

4^th World Congress on Virology

October 06-08, 2014 Hilton San Antonio Airport, TX, USA

Zsolt Boldogkői, Dóra Tombácz, Zsolt Csabai, Péter Oláh and Michael Snyder

Posters: J Antivir Antiretrovir

Abstract :

Earlier we proposed that the transcriptional interactions form a network play important roles in the regulation of global gene expression in all taxa of living beings. We used a herpesvirus model for the investigation of this issue. The genome of pseudorabies virus (PRV) is very compact. We have shown that most of the PRV transcripts overlap with each other in various manners including convergent, divergent and parallel orientations. We have shown that this interactions result in a inverse pattern of gene expressions. We used the following techniques for these investigations: Real-time RT-PCR, Illumina HiScanSQ and PacBio RS II platforms. This work was supported by Swiss-Hungarian Cooperation Programme (SH/7/2/8) to ZB, co-financed by the European Social Fund in the framework of TÁMOP-4.1.1.C-13/1/KONV-2014-0001 to ZB and TÁMOP 4.2.4. A/2-11-1-2012-0001 ?National Excellence Program? to DT.