Medicinal & Aromatic Plants
Open Access
ISSN: 2167-0412
ISSN: 2167-0412
Cho Hyun-Ki
Chungbuk National University, Republic of Korea
Posters & Accepted Abstracts: Medicinal & Aromatic Plants
Introduction & Aim: Turmeric (Curcuma longa) is an herbaceous perennial plant belonging to the ginger family, Zingiberaceae and is commonly used as a culinary spice, as well as in food coloring. Black pepper (Piper nigrum) is a flowering vine of the family Piperaceae, which is usually dried and used as a culinary spice. Co-administration of piperine and curcumin, which are the main constituents of black pepper and turmeric, respectively, has been shown to enhance the bioavailability of curcumin by 2000% in humans and 154% in rats. We evaluated the growth inhibitory effect of turmeric and black pepper ethanolic extracts on A549 and NCI-H292 cell lines. Methodology & Theoretical Orientation: The turmeric and black pepper powder was extracted with 70% ethanol with yields of 26.3% and 14.3%, respectively. In order to confirm the specific toxicity toward lung cancer cells, the turmeric and black pepper ethanolic extracts were exposed to two lung cancer cell lines (A549 and NCI-H292), as well as to normal human lung fibroblast cell line for 24 hours. Results: At a concentration of 100 μg/mL viability of normal lung fibroblasts was 87.1±5.7%, while those of A549 and NCI-H292 cells were 57.0±3.3 and 62.7±9.4%, respectively. Conclusion & Significance: Co-treatment of turmeric and black pepper ethanolic extracts showed a synergistic effect on lung cancer cell cytotoxicity. Our study confirmed the effects of turmeric and black pepper ethanolic extracts on lung cancer cell death through synergistic effects and provides a basis for further study.
Cho Hyun-Ki is studing master's course in Chungbuk National University, Republic of Korea. He is one of staff in the Tobacco Smoke Analysis Center, an internationally recognized testing laboratory (KOLAS, KS Q ISQ / IEQ 17025), which analyzes the smoke components of all tobacco produced in Republic of Korea.
E-mail: a58713800@chungbuk.ac.kr