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Mohamed Labib Salem
Tanta University, Egypt
Posters & Accepted Abstracts: J Hematol Thrombo Dis
Acute lymphoblastic leukemia (ALL) is the most common cancer diagnosed in children. The precise mechanism behind the relapse in this disease is not clear. One possible mechanism could be the accumulation of regulatory cells including myeloid-derived suppressor cells (MDSCs) and T regulatory cells (Tregs), which we and others have reported to mediate suppression of anti-tumor immune responses. In this study, we aimed to analyze the numbers of these cells in a group of Egyptian B-ALL pediatric patients (n=45). Using multiparametric flow cytometer, MDSCs and Tregs cells were defined as Lin- HLA-DR-CD33+CD11b+ and CD4+CD25+CD127-/low, respectively. B-ALL patients showed significant increases in the numbers of MDSCs and Tregs when compared to healthy volunteers. During induction of chemotherapy, the numbers of these cells were increased and decreased, respectively. After induction of chemotherapy, the numbers of MDSCs and Tregs cells were significantly higher and lower, respectively, as compared to the healthy controls. Our results indicate that B-ALL patients harbor higher numbers of both MDSCs and Tregs cells and these levels are changed after chemotherapy. This pilot study opens a new avenue to investigate the mechanism mediating the emergence of these cells on larger number of B-ALL patients in particular during and after chemotherapy.
Email: mo[email protected]