Incidence of multi-resistant Acinetobacter and Pseudomonas isolat | 19150
Journal of Drug Metabolism & Toxicology

Journal of Drug Metabolism & Toxicology
Open Access

ISSN: 2157-7609


Incidence of multi-resistant Acinetobacter and Pseudomonas isolates from clinical samples at the hospital complex in Jaen

Joint Event on 31st Euro Global Summit and Expo on Vaccines & Vaccination & 4th World Congress and Exhibition on Antibiotics and Antibiotic Resistance

June 14-16, 2018 Barcelona, Spain

Morales Hervas Laura, Cobo Molinos Antonio, Roldan Fontana Carolina, Liebanas Martos Carmen, Galvez del Postigo Ruiz Antonio and Ortega Morente Elena

Universidad de Jaen, Spain
Hospital of Jaen, Spain

Posters & Accepted Abstracts: J Drug Metab Toxicol

Abstract :

Introduction & Aim: The emergence and spread of antibiotic resistance among human pathogens is a relevant problem for human health. Virulent Acinetobacter and Pseudomonas are frequently life-threatening and often challenging to treat, so the emergence of multidrug-resistant isolates among these genera represents a critical problem. The aim of this study was to analyze the incidence of multi-resistant Pseudomonas and Acinetobacter isolates from clinical samples processed at the Hospital Complex of Ja�?�?�?�?�?�?�?©n. Methodology: Bacterial strains were isolated from clinical samples and subsequently identified by Malditoff (Matrix-Assisted Laser Desorption/Ionization Time-Of-Flight), with a Microflex series bench-top (Bruker, Bremen, Germany). Background antibiograms used as a reference guide for empirical selection of antibiotics were adopted to identify those strains with antibiotic multi-resistance. Results: Acinetobacter baumannii and Pseudomonas aeruginosa accounted for nearly 50% of antibiotic multi-resistant isolates obtained during the study (25.9% and 23.4%, respectively). 100% of isolates identified as Acinetobacter baumannii were resistant to Ampicillin, Ticarcillin, Piperacillin / Tazobactam, Ceftazidime, Cefotaxime, Cefepime, Aztreonam, Doripenem, Ciprofloxacin, Levofloxacin and Tigecycline. More than 90% of the isolates were also resistant to Imipenem, Meropenem, Gentamycin and Amikacin. 100% of Pseudomonas aeruginosa isolates were resistant to Ampicillin, Cefotaxime, Tigecycline, Minocycline and Trimethoprim/Sulfamethoxazole. High percentages were also classified as resistant to all the carbapenemic antibiotics tested as well as to levofloxacin. Conclusions: Results from the present study show a high prevalence of antibiotic multi-resistant Acinetobacter and Pseudomonas isolates, and corroborate the urgent need for new antibiotics.

Biography :

Morales Hervás Laura is a PhD student at the University of Jaén. Her research field is Antibiotic Resistance in clinical isolates.