Incidence and characterization of multi-drug resistance Acinetoba | 18266
Journal of Drug Metabolism & Toxicology

Journal of Drug Metabolism & Toxicology
Open Access

ISSN: 2157-7609

Incidence and characterization of multi-drug resistance Acinetobacter Baumannii

3rd World Congress and Exhibition on Antibiotics and Antibiotic Resistance

July 31-August 01, 2017 | Milan, Italy

Mohammad Al-Tamimi, Kamal Hijamwi and Heather Lee Harvey

Hashemite University, Jordan

Posters & Accepted Abstracts: J Drug Metab Toxicol

Abstract :

Objectives: A. Baumannii is a common cause of infections associated with high mortality and morbidity. It is an important multi-drug resistant microorganism worldwide. The aim of this study is to investigate the incidence and characterization of A. Baumannii in a tertiary Hospital in Jordan. Methods: Retrospective study using data available on Vitek 2 compact system and patients files from 2010 to 2016 in Specialty Hospital, Amman. Demographic, clinical, isolates information and antibiotics sensitivity patterns were collected and analyzed using appropriate statistical tests. Results: 622 A. Baumannii isolates were reported during the study period with about 99% having high confidence rate. Most isolates were from male, aged 18-60 years, Jordanian, and from infected wounds in surgery and critical care departments. 76.8% of A. Baumannii isolates were MDR. Adults over 60, male, non-Jordanians, critical ill patients and infected wounds represented significant risk factors for MDR incidence (P<0.0001), while no statistical significant risk associate with years (P=0.3933). Resistance pattern indicated high resistance for most cephalosporins, carbapenems fluoroquinolones, and ampicillin, moderate resistance for trimethoprim/sulfamethoxazole and ampicillin/sulbactam low resistance for aminoglycosides and tetracyclines, and the lowest resistance rates were for colistin and tigecycline. Most strains had aminoglycosides resistant phenotype GENNET- AMI-TOB, GEN-TOB-AMI and TOB-GEN-NET. Conclusion: Jordan has high rate A. Baumannii MDR. Adults, critically ill males with infected wounds had significant high rate of A. Baumannii MDR. Continued surveillance and monitoring of this critical microorganism is required.

Biography :