Medicinal & Aromatic Plants
Open Access
ISSN: 2167-0412
+44 1300 500008
ISSN: 2167-0412
+44 1300 500008
Umbreen Rashid, Muhammad Rashid Khan, Jasia Bokhari and Shumaila Jan
GC Women University, Pakistan
Quaid-i-Azam University, Pakistan
Scientific Tracks Abstracts: Med Aromat Plants
Objective & Purpose: The crude methanolic extract of Fagonia olivieri and its derived fractions were evaluated for their antiinflammatory potential in Sprague-Dawley rats. Materials & Methods: Carrageenan induced hind paw edema model was employed to determine anti-inflammatory activity of extracts. Results: The ethyl acetate fraction showed highest inhibition (25.516%) among all the extracts compared to the control rats. The standard drug Diclofenac Potassium (10 mg/kg bw) showed 35.106% inhibition. The aqueous and n-butanol fractions produced 21.512 and 10.983% inhibition respectively. The least value of inhibition was shown by methanol extract (3.853%). Conclusion & Discussion: The significant anti-inflammatory effect revealed by the ethyl acetate and aqueous fractions of Fagonia olivieri may be due to inhibition of prostaglandin-like substances. Anti-inflammatory potential could be assigned to chemical compounds like flavonoids, tannins, saponins, triterpenes and sterols. Tannins and flavonoids are known to inhibit prostaglandin synthesis.
Umbreen Rashid has completed her PhD at Quaid-i-Azam University, Islamabad, Pakistan. She worked as a Research Fellow at Cardiff School of Chemistry, Cardiff University, Wales, UK. She is an Editorial Board Member (invited) of 11 international journals. She is a Reviewer of various international journals and launched the Department of Environmental Sciences at GC Women University, Sialkot, Pakistan. She is currently working as an Assistant Professor in the Department of Zoology, GC Women University, Pakistan. Her research interests include medicinal plants, pharmacology and toxicology.
E-mail: umbreen.rashid@gmail.com