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Rush University Medical Center, USA
Posters & Accepted Abstracts: J Clin Exp Dermatol Res
Antithrombin (AT) is a natural anticoagulant which has both anticoagulant and anti-inflammatory properties. After thermal injury, the body sustains a Systemic Inflammatory Response Syndrome (SIRS), which activates coagulation and fibrinolysis, resulting in subclinical disseminated intravascular coagulation (DIC). There is a depletion of the coagulation factors and an increase in fibrinolytic debris in the vasculature. In burn patients, who have been treated with human Antithrombin concentrate compared to controls who have not received AT concentrate, there has been a decrease in thromboses under the burnt skin and a resulting enhancement of the healing process. The role of skin pathology, cytokines, the coagulation system, shock proteins and CD markers is discussed.
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