Imatinib-induced pemphigus foliaceus in a patient with gastrointe | 11359
Journal of Clinical & Experimental Dermatology Research

Journal of Clinical & Experimental Dermatology Research
Open Access

ISSN: 2155-9554

+44 1478 350008

Imatinib-induced pemphigus foliaceus in a patient with gastrointestinal stromal tumor

17th European Dermatology Congress

March 01-03, 2018 | Paris, France

Wen-Shan Chen

Taichung Veterans General Hospital, Taiwan

Scientific Tracks Abstracts: J Clin Exp Dermatol Res

Abstract :

A 59-year-old man was diagnosed one-year-ago with a gastrointestinal stromal tumor (GIST) and liver metastasis. Since the diagnosis, he has been under an oral, Imatinib 400 mg daily treatment without any concomitant medications or special health food. A half year into the treatment, he was presented to our dermatology clinic due to progressing, non-pruritic scaly eroded eruptions over his upper back and abdomen. An incisional skin biopsy taken from the lesion over his back revealed a subcorneal cleft with acantholysis, along with dyskeratotic cells in the granular layer of the epidermis. Direct immunofluorescence revealed remarkable intercellular deposits of both immunoglobulin G (IgG) and C3 within the upper epidermis, but without the deposits of IgM and IgA. Indirect immunofluorescence showed circulating IgG anti-intercellular substance antibodies at a titer of 1:160. A careful correlation between the clinical and pathologic pictures suggested a diagnosis of Imatinib-induced pemphigus foliaceus (PF). In summary, to the best of our knowledge, this is the first case of Imatinib-induced PF ever reported in literature. We strongly believe that any observation of scaly, erytheamtous maculopapules in patients under Imatinib treatment should alarm the caring physicians, in light of the increasing popularity of prescribing this novel anticancer drug.

Biography :

Wen-Shan Chen is working as Professor of Geology, Taiwan University, previously he was working as associate professor at Department of Geology, National Taiwan University.