Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
A Wajda, A Paradowska-Gorycka, A Sowinska, B Stypinska, A Lutkowska, M Walczyk, M Olesinska, P Piotrowski, M Puszczewicz,D Majewski and P P Jagodzinski
National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw, Poland
Poznan University of Medical Sciences, Poznan, Poland
Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland
Posters & Accepted Abstracts: J Clin Cell Immunol
In systemic lupus erythematosus (SLE), the immune responses, immune homeostasis and self-tolerance is actively regulated by several types of cells as well as cytokines. The aim of our study was to explore whether IL-1, IL-10 and TNFα genetic variants may be associated with SLE. We examined 216 patients with SLE and 552 unrelated healthy controls. The polymorphisms were evaluated by RT-PCR. The IL-1β rs16944 T allele as well as rs1143634 T allele were significantly frequent in SLE patients than controls (p=0.003 and p=0.017, respectively). The IL-10 rs180872 A allele was more frequent in SLE patients (p=0.003), furthermore, the IL-10 rs1800896 G allele was more frequent in controls (p=0.03). The TNF-α rs1800629 A allele was more frequent in SLE patients than in controls (p=0.002). No association was found between of the TNF-α rs361525 and rs1800610 and SLE susceptibility. The genotype-phenotype analysis showed association between the IL-1β rs1143634 and mean value of C3 (p=0.006); the IL-10 rs180872 and AST (p=0.07); the IL-10 rs1800896 and mean value of C4 (p=0.04); TNF-α rs361525 and SLICC (p=0.02); the TNF-α rs1800610 and Pt (p=0.003) and INR (p=0.004). Our study demonstrated that IL-1β and IL-10 genetic variants are associated with SLE susceptibility in Polish population
Anna Wajda, PhD is an assistant professor at the Molecular Biology Department, National Institute of Geriatrics, Rheumatology and Rehabilitation in Warsaw, Poland. She has received her PhD in the field of medical biology from Pomeranian Medical University in Szczecin, Poland. Over the past few years, she has done research in Toxicology, Medical Technology and Clinical Pharmacology.Dr. Wajda currently focuses on genetic factors in the function of the immune system and autoimmune diseases.
E-mail: annawajda2046@gmail.com