Human herpesvirus type 8 (HHV-8/ KSHV) in patients with decompens | 872
Journal of Antivirals & Antiretrovirals

Journal of Antivirals & Antiretrovirals
Open Access

ISSN: 1948-5964

Human herpesvirus type 8 (HHV-8/ KSHV) in patients with decompensated cirrhosis

International Conference and Exhibition on VIROLOGY

5-7 September 2011 Baltimore, USA

Cheng-Chuan Su

Scientific Tracks Abstracts: JAA

Abstract :

To date, human herpesvirus type 8 (HHV-8; Kaposi?s sarcoma-associated herpesvirus, KSHV) DNA has been consistently found in all types of Kaposi sarcomas. Th ese neoplasms sometimes develop in patients without AIDS with variable immunologic abnormalities aft er corticosteroid, cytotoxic, or immunosuppressive therapy for malignancies, tissue transplants, or autoimmune diseases. Immunologic disturbances with impairment of immune function associated with spontaneous bacterial peritonitis and a higher incidence of lymphoproliferative disorders and other malignancies have been described in patients with cirrhosis. However, the prevalence of HHV-8 infection in patients with cirrhosis has not been previously described. Our study found that signifi cantly more patients with decompensated cirrhosis are seropositive for HHV-8 antibodies than healthy controls (P = 0.0018). Antibody titers in the cirrhotic patients are also signifi cantly higher than those in the controls (P = 0.0006). Male patients seropositive for HHV-8 antibody are signifi cantly younger than seropositive female patients (P = 0.0039). Th e seropositive rate for HHV-8 antibody seems to be increased with cirrhosis severity. Th e seropositive rate in cirrhotic patients is not associated with thrombocytopenia (P = 0.6860). Th ere are no signifi cant diff erences in mean lymphocyte, monocyte, or platelet counts between seronegative and seropositive healthy controls and cirrhotic patients. Th e seropositive rates between cirrhotic patients with and without lymphopenia, monocytosis, or thrombocytopenia are also not statistically diff erent. Both positive rate and titers of antibodies in cirrhotic plasma samples are much greater than in ascites samples (P <0.0001). All patients with positive ascites are seropositive. More male or Child?Pugh class C than female or class B seropositive patients are positive for ascites. No hepatitis C virus-related ascites are positive for antibody. Neither plasma nor ascites specimens from any subject are positive for HHV-8 DNA. Seropositivity is not associated with clinical manifestations of HHV-8 infection, such as KS, primary eff usion lymphoma, or multicentric Castleman disease.

Biography :

Cheng-Chuan Su has completed residency training in Anatomic Pathology at the age of 31 years from National Cheng Kung University Hospital and training in Clinical Pathology at the age of 33 years from National Taiwan University Hospital. He is the Medical Director of Department of Clinical Pathology and the Attending Doctor, Department of Anatomic Pathology, Buddhist Dalin Tzu Chi General Hospital, Chiayi and the lecturer of Departments of Laboratory Medicine and Pathology, School of Medicine, Tzu Chi University, Hualien, Taiwan. He has published more than 25 papers in reputed journals.